Annotated Medical Bibliography
By Dr. Alan Inglis, MD

I like to describe important minerals such as zinc as key multitaskers in our bodies.This means they play a role in many different aspects of our physiology and health. And I always like to know if the research points to the likelihood of people not getting enough of a particular mineral of interest, such as zinc. 

One the most important roles of zinc in our bodies is as a key player in our immune system. In addition, zinc is one of those nutrients many of us just don’t have enough of in our bodies, due to changes in eating habits, aging and medication use. 

When I look at the research that supports the use of zinc especially for the common cold, I am reassured by the strong positive signals coming from the excellent Cleveland Clinic and the prestigious Cochrane Collaborative, the world’s pre-eminent evidence-based medicine organization. For these reasons it only made good sense for us to include zinc -- properly dosed -- in Dr. Schnuffie’s Cold + Flu Remedy.

-- Dr. Alan Inglis


Eby GA, Davis DR, Halcomb WW. Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study. Antimicrob Agents Chemother. 1984;25:20–24. 

Fendrick AM, Monto AS, Nightengale B, et al. The economic burden of non-influenza-related viral respiratory tract infection in the United States. Arch Intern Med. 2003;163:487–494.

Goutham Rao, MD and Kate Rowland, MD, John Hickner MD, Cleveland Clinic 'Zinc for the common cold -- not if but when.' J Fam Pract 2011 November

Hemila H. Zinc lozenges may shorten the duration of colds: a systematic review. Open Respir Med J. 2011;5:51–58.

Jackson JL, Lesho E, Peterson C. Zinc and the common cold: a meta-analysis revisited. J Nutr. 2000;130 (5 suppl):1512S–1515S.. 

Marshall S. Zinc gluconate and the common cold. Review of randomized controlled trials. Can Fam Physician. 1998;44:1037–1042.

Singh M, Das RR. Zinc for the common cold. Cochrane Database Syst Rev. 2011;(2):CD001364.

Singh M, Das RR. Clinical potential of zinc in prophylaxis of the common cold. Exp Rev Resp Med. 2011;5:301–303..For more information on zinc and the common cold see: http://lpi.oregonstate.edu/mic/minerals/zinc#disease-treatment

Phytate, which is present in staple foods like cereals, corn and rice, has a strong negative effect on zinc absorption from composite meals.For more information see: https://www.ncbi.nlm.nih.gov/pubmed/10801947 May 8 2012